Background: PC gamer with desk based job with wrists that have deteriorated to the point where a regular mouse is very uncomfortable to use. I have used gaming mice from all the major providers over the years, as well as some of the common ergonomic recommendations such as the Posturite Penguin and various iterations of trackballs.I had been eyeing up the Anker vertical mouse but was put off by the limited DPI selections and then I saw this. I paid £19.99 and honestly it is hard to find a fault with the mouse, particularly at this price. The shape is comfortable and does not cause me any wrist discomfort, it is easy to maintain a neutral non-gripping hand position and use the mouse effectively.The RGB strobe that it comes with out of the box is a minor irritation, but the software download available for the mouse allows it to be disabled. More importantly, the software allows customisation of the DPI (and to set colour indications for the different settings) and roles of each of the buttons, which can then be saved to the mouse. This works across computers, useful if you, like me, have a personal PC that you can install software on and a work PC that you cannot.The main buttons seem to have decent quality switches and a comfortable actuation pressure. The scroll wheel is adequate, not of the quality that you'd get on a high end mouse, but that's not what you're paying for here. I don't know what sensor is in the mouse, but it is good enough for FPS games and the sensor position under the hand feels natural, unlike with the Penguin mouse.TL;DR - if you have wrist issues and you're used to quality, software-customisable, gaming mice for whatever purpose, give this a shot. It would still be a good purchase at £40 and I hope the other companies follow suit with their own versions.